Hormone Alternative Throughout Perimenopause: One Lady’s Story


A pair months in the past, I used to be driving to work, listening to the Huberman Lab podcast, and my ears perked up a bit greater than regular after I heard his visitor, Dr. Peter Attia, rattle off a listing of the reason why the Girls’s Well being Initiative research was a scorching mess. A couple of weeks later, I heard Dr. Huberman interview Dr. Sara Gottfried, who supplied the same opinion of the Girls’s Well being Initiative, and shared her practical drugs strategy to hormone remedy.

When you’re new to the subject, the Girls’s Well being Initiative was a landmark research that adopted an enormous group of girls over the course of 15 years, investigating the consequences of hormone substitute on outcomes like heart problems, bone density, and most cancers in perimenopausal and postmenopausal ladies. The findings of the research, together with issues like an elevated threat of breast most cancers and cardiovascular occasions like strokes and coronary heart assaults, brought about a substantial amount of concern within the medical group. The research additionally obtained an enormous quantity of media consideration, which amplified these issues not solely amongst physicians, but in addition among the many normal public. When you’re fascinated with why Dr. Attia and Dr. Gottfried each thought the research design and information interpretation have been flawed, it is best to undoubtedly take heed to their full episodes right here and right here. However the takeaway is that this: too many docs and perimenopausal ladies have been terrified to make use of hormones for too lengthy, and it is likely to be time to rethink issues. The New York Instances agrees. 

Ought to all ladies take hormones?

Does this imply hormone remedy is correct for everybody? Completely not, and there are many folks for whom hormones are both contraindicated or ill-advised, so it’s a choice that must be made together with your healthcare supplier. On this put up, I’ll share why I appeared into hormone substitute remedy for myself, why I lastly determined to offer it a strive, and what I’ve skilled to this point. To be clear, this put up does not represent medical recommendation, or function my place assertion on the difficulty. It’s simply the story of a 49-year-old girl (with a medical diploma) and her private journey to navigate the turbulent waters of perimenopause. 

What are the signs of perimenopause?

The signs of perimenopause, just like the signs of premenstrual syndrome, are totally different for everybody. Frequent complaints embrace scorching flashes, breast tenderness, cycle irregularities (shorter, longer, heavier, skipped), sleep disturbances, temper disturbances, anxiousness, and diminished libido or painful intercourse. My signs have been pretty manageable, however the lack of sleep and heightened anxiousness have been beginning to put on me down. I might go to sleep, however woke at 2am most nights and my mind thought that was time to work out all the issues of the universe. I used to be additionally getting my interval each 21 days, with extraordinarily sore boobs for ten days of every cycle, and a debilitating dose of irritability and cramps after I began bleeding. I had realized to reside with this sample, as many people do, however it wasn’t notably enjoyable for anybody in my home.

The place do I get hormone substitute remedy?

Begin with the healthcare supplier who does your pap smears. I spoke with my OB/GYN, whom I am keen on, and she or he undoubtedly had a extra conventional tackle HRT than Sara Gottfried or Peter Attia. Her suggestion, which is customary observe in most locations, was to not verify ranges, however to deal with the signs, and begin me on oral contraceptives, aka contraception drugs consisting of progestin and ethinyl estradiol, artificial variations of progesterone and estrogen. As a result of I spent loads of years on the tablet as a younger ladies, and since the strategy felt a bit non-specific for my medically-trained, overanalyzing mind, I by no means picked up the prescription. As a substitute, I did a bit extra analysis.

What’s bioidentical hormone remedy, aka BHRT?

Also referred to as bioequivalent hormone remedy, this strategy makes use of hormones which are structurally equivalent to the hormones your physique naturally produces, like estrogen, progesterone, DHEA, and testosterone. Standard hormone substitute remedy makes use of totally different molecules, akin to progestin and ethinyl estradiol. Is one higher than the opposite? Based on the present medical literature, there isn’t a proof to point out that bioidentical hormone remedy is superior to traditional remedy. That stated, it makes intuitive sense to me that utilizing hormones my physique is already manufacturing might have a greater security profile, even when we don’t have the information to assist that idea but.

What’s the practical drugs strategy to hormone remedy?

Over the past quarter-hour of a webinar with Sara Gottfried, she instructed ifm.org as a useful resource for locating a practical drugs practitioner. The closest one to me was an OB/GYN a couple of hours away, however we did a digital session, and shortly had rapport. She had a extra particular plan, beginning with bloodwork. 

The lab panel she ordered on day three of my quick cycle was about $180 and included primary labs like a CBC and CMP, in addition to ranges of Vitamin D, DHEA, DHT, free testosterone, progesterone, estradiol, lipoprotein (a), apolipoprotein B, and homocysteine. I shared the outcomes of a latest lipid panel together with her, as nicely. Oof, that was loads of medical phrases, however principally she wished to ensure my bloodwork was regular, and get a baseline sense of my hormones and my cardiovascular threat. I additionally answered a few billion questions on my well being, from weight loss program to emphasize ranges to an intensive household historical past. I used to be actually impressed with how a lot homework she was doing earlier than doling out the hormones. Cardiovascular threat components, a household historical past of most cancers, and blood glucose regulation matter when contemplating the potential dangers and advantages of hormone remedy, so I used to be glad to know my physician was attempting to know the entire image of ME—one thing many standard docs neglect as a result of an unlucky lack of time, coaching (belief me, I went to medical faculty), and sources.

When my labs got here again, it turned out that I used to be estrogen-dominant, and my progesterone was nearly non-existent. My DHEA and testosterone have been each trending low, as was my Vitamin D degree. My cardiovascular threat numbers appeared superior, and I had no indicators of glucose dysregulation. 

So, what did I do with all this data? Like scientist, I modified tons of issues on the identical time!! Right here’s how we obtained began on my perimenopausal campaign:

  • I began taking bioequivalent progesterone, 100mg each night time. Since we’re hoping to elongate my cycle a bit, I’ve been on it for a month straight now, however will doubtless take a couple of days off every month ultimately. The prescription I’ve is for a vegan pill (I don’t do gelatin), and got here from a compounding pharmacy. 
  • I began DHEA, 25mg day by day. (This can be a pretty low dose.) At first, I took it within the morning, however then discovered I slept higher after I took it with my progesterone at night time. It suppresses cortisol, and may enhance the hole between your bedtime cortisol and waking cortisol, which can enable you to really feel extra rested. DHEA can also be utilized by your physique to make estrogen and testosterone, and may be thought-about as an alternative choice to testosterone supplementation to assist athletic efficiency and libido, though the information to assist both is blended.
  • I began a Vitamin D complement, particularly one which accommodates A, D, and Ok, three of the 4 fats soluble nutritional vitamins we want. Every capsule accommodates 5000 IU of Vitamin A, 5000 IU of Vitamin D3, and 500 mcg of Vitamin K2, and I take one about 4-5 instances every week.
  • No practical drugs physician can get by way of a dialog with out mentioning intestine well being, and now we have a complete intestine rehab factor going, which I feel could require a separate weblog put up. Briefly, my intestine is as leaky as my eyes after I watch This Is Us, so we’re actively engaged on the state of affairs. 
  • To scrub down my progesterone and DHEA, I take a bit cocktail of magnesium chelate, glycine, N-acetylcysteine, and cranberry focus. It’s my nightcap, and it’s reasonably scrumptious. 

Facet notice: my physician prescribed all however the progesterone by way of Fullscript, a complement web site. Whereas suppliers do get a bit reduce of something I buy there, the positioning affords discounted pricing on numerous dietary supplements, subscriptions for something you are taking usually, and ships in a short time. I used my HSA card to buy the dietary supplements, in order that helped a bit, too!

Will hormone substitute remedy assist me sleep?

I don’t know what you’ll discover with HRT, however I’ll let you know what I’m noticing: SLEEP. Each the standard and the amount of my sleep have improved dramatically since I began hormones. It’s solely been a month, however I can’t even let you know how good it feels to sleep once more! Since I began medical faculty in 1997, my sleep has been irregular. Since I had children in 2003 and 2007, my sleep has been interrupted. Since I began a enterprise in 2012, my sleep has been laced with stress goals. For the reason that world fell aside in 2020, my sleep has been fitful and woven by way of with an ever-present fridge hum of hysteria. And since I began perimenopause, each time that occurred, the anxiousness hum has gotten louder and more durable to handle, particularly throughout these 2am fear periods. 

Since I began progesterone and DHEA, it looks like every little cell in my physique will get in mattress, blows out a wee candle, and tucks itself in for the night time. Once I get up, I really feel rested, however not groggy. And that 4pm vitality droop is now the exception as a substitute of the rule. Like I stated, I modified loads of issues directly, so that is under no circumstances an ideal experiment. However I do have some information to point out that it’s not all in my head! The screenshots under are from my Whoop, the little information gathering sensor I put on on my wrist each day. 

Right here’s a median month of sleep earlier than I began hormones:

graph of sleep performance before starting hormone therapy

one month of sleep data before starting hormone therapy

And right here’s what issues appear like since I began taking hormones and my nightly magnesium potion:

sleep patterns after starting hormone therapy

sleep performance after starting hormone therapy

I like this development, and I hope it continues! 

Does hormone remedy assist anxiousness?

I don’t have information to assist this but. (Whoop simply launched a “stress monitor” characteristic, so possibly I’ll have information quickly.) Subjectively, I’d say my anxiousness is barely improved since beginning hormones. For the report, I meditate and train 5-6 instances every week, so I’m actively engaged in stress administration, and my anxiousness has by no means been crippling or required medicine of any type. However, whereas my causes for worrying haven’t modified, the interior quantity at which I do my worrying appears to have decreased by a notch or two. I’ll take it, and I’m hoping this development continues as nicely.

Does hormone remedy assist with intercourse drive?

The best cocktail of hormones can undoubtedly enhance intercourse drive, also referred to as libido. As for me, I don’t know but. My intercourse drive is first rate. I imply, generally I’ve to do what I name “getting over the hump to hump,” which means that it takes a little bit of acutely aware vitality on my half to get issues going, however as soon as the engine is began, intercourse is superior! That stated, I need to ensure that our intercourse life stays energized as we become old, so I’m taking DHEA to assist each libido and athletic restoration. DHEA is an androgen hormone that we make in our our bodies naturally, and serves as a precursor for each estrogen and testosterone, so it’s like taking the lengthy highway to an elevated libido. However for some motive, I didn’t really feel prepared to start out testosterone but, and I undoubtedly wasn’t fascinated with testosterone pellets, a way that permits no nuance or changes as your physique reacts to the remedy. After a month of DHEA, I haven’t seen a lot of a change in libido particularly, so I’ll hold engaged on it with my physician. Facet notice: my husband is watching me sort this paragraph, and he needs you to know he’s holding up his finish of the cut price.

Does hormone remedy have unwanted effects?

All the pieces has unwanted effects, or not less than the potential for unwanted effects. With the primary month of this progesterone + DHEA routine, which I began on the primary day of my cycle, I skilled about 14 days of low-grade bleeding and my boobs have been considerably much less sore. Once I obtained my interval once more, it got here a bit later, and cramping was minimal. Aside from these “unwanted effects,” I’ve had none—hallelujah! I think about that would change if I elevated the dose or added estrogen, however for now, I’m not experiencing any unpleasantness in any way.

Remember that antagonistic penalties of hormone remedy aren’t thought-about unwanted effects. These would come with issues like blood clots (not going with progesterone-only remedy) or the event of breast most cancers or endometrial most cancers, and are the principle causes a person threat evaluation is critical earlier than beginning HRT. Fortunately, I used to be candidate, with no private or household historical past of blood clots or hormone-related cancers. 

How lengthy ought to I keep on hormone substitute remedy?

Once more, this query will get answered on a case-by-case foundation. I’m nonetheless menstruating month-to-month, and HRT received’t change when my physique goes by way of menopause. Enjoyable truth: menopause is a at some point occasion—the day when you haven’t had a interval for one 12 months. Some ladies keep on for six months, others for ten years—the concept of hormone remedy is to clean the sharp edges of your transition to a post-menopausal state, making it a a lot much less bumpy experience. The excellent news is that you simply’re in command of the choice making right here; if you happen to begin HRT and discover that it doesn’t assist or isn’t for you, you may cease it, or work together with your supplier to vary your routine to get the outcomes you need.

So, are you saying I ought to begin hormone remedy?

I’ll say it once more, additional loud for the oldsters within the again: THIS IS NOT MEDICAL ADVICE, OR ME TELLING YOU THAT YOU SHOULD START HORMONE THERAPY. It’s a really private resolution that should be made in collaboration with a licensed medical skilled. Nevertheless it was a complicated panorama for me, even with a medical diploma and ten years of observe beneath my belt. That’s why I wrote this put up—in case it’s useful to listen to another person’s particular story as you write your personal. Ship me a message on Instagram when you’ve got any questions—glad to reply them if I can!

With love and glad hormone ranges,


Leave a Reply

Your email address will not be published. Required fields are marked *